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Therapeutics targeting oxidative stress hold great promise for the treatment of DR but have not yet been translated into clinical practice

Identified GPX homologs belonged to the GSHPx (PF00255) protein family

Furthermore, TRPA1 contributes to resistance to chemotherapies that generate ROS, while the inhibition of TRPA1 leads to a reduction in tumor growth and an increase in sensitivity to chemotherapy

To encapsulate therapeutic chemicals while reducing off-target effects, POx-based drug delivery systems use their amphiphilic nature to self-assemble into nanostructures such as micelles, polymersomes, and polyplexes

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The R144C change in the CYP2C9 * 2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase